Leading Edge Antioxidants Research

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Nova Publishers, 2007 - 266 Seiten
In biological systems, the normal processes of oxidation (plus a minor contribution from ionising radiation) produce highly reactive free radicals. These can readily react with and damage other molecules. In some cases the body uses free radicals to destroy foreign or unwanted objects, such as in an infection. However, in the wrong place, the body's own cells may become damaged. Should the damage occur to DNA, the result could be cancer. Antioxidants decrease the damage done to cells by reducing oxidants before they can damage the cell.Virtually all studies of mammals have concluded that a restricted calorie diet extends the lifespan of mammals by as much as 100 percent. This remarkable finding suggests that food is actually more damaging than smoking. As food produces free radicals (oxidants) when metabolised, antioxidant-rich diets are thought to stave off the effects of ageing significantly better than diets lacking in antioxidants. The reduced levels of free radicals, resulting from a reduction in their production by metabolism, is thought to be a major cause of the success of caloric restriction in increasing life span. Antioxidants consist of a group of vitamins including vit

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Inhalt

ANTIOXIDANTS THERAPY FOR CHRONIC INFLAMMATORY DISEASES
145
IMPACT OF OXIDATIVE STRESS ON DIABETES MELLITUS AND INFLAMMATORY BOWEL DISEASES
179
INDEX
247
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Seite 171 - The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 342:154-160 Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G (2000b) Effects of an angiotensinconverting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients.
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Seite 173 - Steinberg D. Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.
Seite 236 - I; MacNee, W. Oxidative stress and regulation of glutathione in lung inflammation.
Seite 173 - Inhibition of hypercholesterolemia-induced atherosclerosis in the nonhuman primate by probucol I. Is the extent of atherosclerosis related to resistance of LDL to oxidation? J Clin Invest l994; 94:l55-l64.
Seite 171 - S et al. Effect of vitamin E and beta carotene on the incidence of primary nonfatal myocardial infarction and fatal coronary heart disease.
Seite 63 - Attachment of Escherichia coli O157:H7 to lettuce leaf surface and bacterial viability in response to chlorine treatment as demonstrated by using confocal scanning laser microscopy.
Seite 171 - Hennekens CH, Buring JE, Manson JE, et al: Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease.

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