Inhibitors of Molecular Chaperones as Therapeutic AgentsTimothy D Machajewski, Zhenhai Gao Royal Society of Chemistry, 23.10.2013 - 352 Seiten This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research. With several small molecule inhibitors in oncology clinical development, there is clearly intense interest in the chaperones as a molecular target. Filling a significant gap in the market by providing a detailed comparison of discovery programs across the industry, this text will find broad interest among researchers in the field of molecular chaperone pharmaceutical research, oncology research, and medicinal chemistry.
|
Inhalt
Chapter 1 Overview of Molecular Chaperones in Health and Disease | 1 |
Chapter 2 Structural Basis of Hsp90 Function | 37 |
Chapter 3 Structure and Function of Hsp70 Molecular Chaperones | 65 |
Chapter 4 Exploiting the Dependency of Cancer Cells on Molecular Chaperones | 126 |
Chapter 5 The Discovery of BIIB021 and BIIB028 | 158 |
Chapter 6 Discovery and Development of Ganetespib | 180 |
Chapter 7 Discovery of the Serenex Hsp90 Inhibitor SNX5422 | 198 |
Chapter 8 Discovery of NVPAUY922 | 213 |
Chapter 10 Inhibitors of the Hsp90 Cterminus | 259 |
Chapter 11 Hsp70 Inhibitors | 302 |
Drug Targeting and Posttranslational Regulation | 318 |
Chapter 13 Hsp90 Inhibitors in Clinic | 336 |
Chapter 14 Heatshock Protein 90 as an Antimalarial Target | 379 |
Chapter 15 Molecular Chaperones as Potential Therapeutic Targets for Neurological Disorders | 392 |
414 | |
Chapter 9 Discovery and Selection of NVPHSP990 as a Clinical Candidate | 241 |
Andere Ausgaben - Alle anzeigen
Inhibitors of Molecular Chaperones as Therapeutic Agents Timothy D. Machajewski,Zhenhai Gao,David P. Rotella Eingeschränkte Leseprobe - 2014 |