Inhibitors of Molecular Chaperones as Therapeutic Agents

Cover
Timothy D. Machajewski, Zhenhai Gao, David P. Rotella
Royal Society of Chemistry, 2013 - 425 Seiten

This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research. With several small molecule inhibitors in oncology clinical development, there is clearly intense interest in the chaperones as a molecular target. Filling a significant gap in the market by providing a detailed comparison of discovery programs across the industry, this text will find broad interest among researchers in the field of molecular chaperone pharmaceutical research, oncology research, and medicinal chemistry.

Arranged into three main sections the book covers structure and function, small molecule inhibitors and concludes with a section discussing clinical perspectives. With specific chapters covering the discovery of key molecules such as, BIIB028, STA-9090, Serenex Hsp90 inhibitor, NVP-AUY922 and NVP-HSP990, this comprehensive text will be an essential treatise for researchers working in academia and industry.

 

Was andere dazu sagen - Rezension schreiben

Es wurden keine Rezensionen gefunden.

Inhalt

_s_h_o_w_7_
7
fig1
10
_s_h_o_w_13_
13
_s_h_o_w_20_
20
fig2
41
fig3
43
fig4
44
fig5
46
sch13
177
fig14
228
fig15
231
fig16
233
fig17
234
fig18
235
fig19
278
fig20
280

fig6
50
fig7
51
fig8
52
fig9
53
fig10
55
fig11
56
fig12
57
fig13
59
sch1
159
sch2
160
sch3
161
sch4
162
sch6
164
sch7
167
sch8
168
sch9
169
sch11
171
sch12
173
fig21
281
fig22
282
fig23
283
fig24
284
fig25
285
fig26
286
fig27
287
fig28
288
fig29
289
fig30
290
fig31
291
fig32
292
fig33
293
fig34
294
fig36
295
_s_h_o_w_308_
308
fig3a
387
Urheberrecht

Andere Ausgaben - Alle anzeigen

Häufige Begriffe und Wortgruppen

Bibliografische Informationen