Inhalation ToxicologyHarry Salem, Sidney A. Katz CRC Press, 22.12.2005 - 1056 Seiten Written by internationally recognized scientists from academic, industrial, and governmental sectors, Inhalation Toxicology, Second Edition details the methods and materials used in the theoretical and applied aspects of inhalation toxicology. The editors emphasize the relationship between the respiratory system and toxicology of inhaled substances |
Inhalt
| 3 | |
2 The Development and Application of Acute Exposure Guideline Levels for Hazardous Substances | 39 |
3 Emergency Response Planning Guidelines ERPGs | 61 |
Applications to Pathogens and Highly Toxic Agents | 73 |
5 LowLevel Effects of VX Vapor Exposure on Pupil Size and Cholinesterase Levels in Rats | 91 |
Nylon Flock as an Example | 109 |
7 The Use of Large Animals in Inhalation Toxicology | 119 |
8 Toxic Load Modeling | 137 |
22 Chemical Warfare Agents and Nuclear Weapons | 521 |
23 The Inhalation Toxicology of Chromium Compounds | 543 |
24 Safety Assessment of Therapeutic Agents Administered by the Respiratory Route | 565 |
25 Nonclinical Pharmacology and Safety Studies of Insulin Administered to the Respiratory Tract | 609 |
26 Inhalation Toxicology of AlcoholGasoline Fuels8212Current Status | 623 |
27 Asbestos | 647 |
28 The Inhalation Toxicity of Benzene | 669 |
29 Carbon Monoxide | 695 |
9 Inhalation Toxicology and Carcinogenicity Studies of the National Toxicology Program | 159 |
10 Toxicology of Fire and Smoke | 205 |
11 Toxicogenomics of LowLevel Nerve Agent Vapor Exposure | 231 |
12 Respiratory Sensitization | 243 |
13 Peripheral Chemosensory Irritation with Particular Reference to Respiratory Tract Exposure | 269 |
14 Role of Cytokines in Pulmonary Infl ammation and Fibrosis Induced by Inhaled Mineral Particles | 307 |
Implications for Risk Assessment | 335 |
16 Nasal Toxicology | 349 |
17 Effects of Inhaled Toxicants on the Nose and Nasal Function | 373 |
Deposition Absorption Distribution and Excretion | 405 |
19 Mechanistic Determinants and Modeling of the Inhalation Pharmacokinetics of Volatile Organic Chemicals | 439 |
20 Inhalation Toxicology of an Irritant Gas8212Historical Perspectives Current Research and Case Studies of Phosgene Exposure | 457 |
21 Inhalation Toxicology of Riot Control Agents | 485 |
30 Experimental Clinical Occupational Toxicology and Forensic Aspects of Hydrogen Cyanide with Particular Reference to Vapor Exposure | 717 |
31 The Pharmacology and Toxicology of Inhaled Dusts Endotoxins and Glucans | 803 |
32 Fluorocarbon Alternatives8212Methodologies for Special Studies and Results | 825 |
33 Animal Models for Three Major CigaretteSmokeInduced Diseases | 851 |
34 The Impact of Active and Passive Exposure to Cigarette Smoke on Maternal and Fetal Health | 875 |
35 Health Aspects of Bioaerosols | 913 |
Natural and Deliberate | 933 |
37 Toxicology Associated with Respiratory Exposures to Fungi Molds | 945 |
38 Inhalation Toxicity of Botulinum Neurotoxin | 963 |
Aerosol Procedures Animal Toxicology and Therapy | 973 |
40 Toxicity Mechanisms Prophylaxis and Therapy of Inhaled Biological Toxins | 983 |
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absorption ACGIH acid activity acute aerosol agents airborne airways alveolar animals Appl Ballantyne benzene biological blood body weights cancer capsaicin carbon monoxide carcinogenicity cause cells chemical chromium chronic chrysotile compounds cyanide cytokines d/week decreased dose dose–response drug duration effects Environ Environmental enzyme epithelium evaluated exposed exposure concentration extrapolation factor female rats fibers fibrosis gases gasoline groups Health hexavalent chromium hormesis hormetic human increased induced inhalation inhalation exposure Inhalation studies inhalation toxicity Inhalation Toxicology injury insulin lethal levels lung macrophages malononitrile mechanism metabolism methanol miosis nasal National Toxicology Program NOAEL NTP National Toxicology occupational olfactory olfactory epithelium oxide particles pharmacokinetic Pharmacol phosgene plasma potential production protein pulmonary receptors reported Respir respiratory tract response riot control agents risk assessment rodents sensitization sensory irritation species tion tissue toxicity Toxicol tumors U.S. EPA values vapor workers