Radiation Oncology: A Physicist's-Eye View

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Springer Science & Business Media, 14.08.2007 - 330 Seiten
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Radiation Oncology: A Physicist's-Eye View was written for both physicists and medical oncologists with the aim of helping them approach the use of radiation in the treatment of cancer with understanding, confidence, and imagination. The book will let practitioners in one field understand the problems of, and find solutions for, practitioners in the other. It will help them to know "why" certain approaches are fruitful while, at the same time, encouraging them to ask the question "Why not?" in the face of assertions that some proposal of theirs is impractical, unreasonable, or impossible. Unlike a textbook, formal and complete developments of the topics are not among the goals. Instead, the reader will develop a foundation for understanding what the author has found to be matters of importance in radiation oncology during over thirty years of experience. Presentations cover, in largely non-technical language, the principal physical and biological aspects of radiation treatment and address practical clinical considerations in planning and delivering therapy. The importance of the assessment of uncertainties is emphasized. Topics include: an overview of the physics of the interactions of radiation with matter; the definition of the goals and the design of radiation therapy approaches; living with uncertainty; biophysical models of radiation damage; computer-based optimization of treatments; and proton therapy. Formulae and quantitation in general have been avoided in the belief that an understanding of the majority of important medical and biological issues in radiation oncology generally cannot be achieved through mathematical relationships. This unique and highly readable book will be indispensable both to beginners and to those with experience in either medical physics or radiation oncology.

The author, who is Professor of Radiation Oncology Emeritus at Harvard Medical School, was an early pioneer in the development of image-based treatment planning and has been responsible for developing and putting into clinical practice such widely used tools as: digitally reconstructed radiographs, dose-volume histograms, and beam’s-eye view and has been a leader in the development of proton beam therapy.

 

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Inhalt

1 RADIATION IN THE TREATMENT OF CANCER
1
2 UNCERTAINTY
13
3 MAPPING ANATOMY
23
4 DESIGNING A TREATMENT BEAM
57
5 BIOLOGY MATTERS
85
6 DESIGNING A TREATMENT PLAN
111
7 MOTION MANAGEMENT
139
8 PLANNING MANUALLY
157
11 PROTON THERAPY IN THE PATIENT
247
12 QUALITY ASSURANCE
287
13 CONFIDENCE
289
AFTERWORD
303
ACKNOWLEDGEMENTS
307
ACRONYMS
309
REFERENCES
311
INDEX
323

9 IMRT and OPTIMIZATION
177
10 PROTON THERAPY IN WATER
211

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Beliebte Passagen

Seite 311 - Late rectal bleeding following combined X-ray and proton high dose irradiation for patients with stages T3-T4 prostate carcinoma.
Seite 319 - Tufte ER 1983. The visual display of quantitative information. Graphics Press, Cheshire, Connecticut. Tufte ER 1990. Envisioning information. Graphics Press, Cheshire, Connecticut. Tufte ER 1997. Visual explanations: Images and quantities, evidence and narrative. Graphics Press, Cheshire, Connecticut.
Seite 311 - Effects of intra-fraction motion on IMRT dose delivery: statistical analysis and simulation. Phys Med Biol 2002:47:2203-2220.

Über den Autor (2007)

Michael Goitein, Ph.D., is Professor of Radiation Therapy Emeritus (Radiation Biophysics) Harvard Medical School. He is certified in Therapeutic Radiological Physics by the American Board of Radiology and in Medical Physics by the Swiss Society of Medical Physics and Biology. He is also a Fellow in the American Association of Physicists in Medicine and an Honorary Member of the Belgian Society of Radiotherapy and Oncology.

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